LOCOMOTION May 2024 Newsletter
LOCOMOTION Public Webinars
As part of the LOCOMOTION Long COVID Study webinar series, on Wednesday 19th June 15:00-16:00 UK time) we will be hosting a webinar on the 'Health Economic Aspects of Long COVID'.
The webinar will contain two presentations by researchers and Patient Advisory Group members from our study, showcasing findings from our study.
PLEASE NOTE: THIS WEBINAR HAS BEEN RESCHEDULED FROM 11TH JUNE TO 19TH, DUE TO TECHNICAL ISSUES WITH THIS WEBINAR SOFTWARE. RE-REGISTRATION IS REQUIRED.
Register for this free webinar now
Visit our Webinar Series page find out about previous webinars and access recordings of them.
LOCOMOTION Publications
Published in BioMed Central (BMC) Medicine.
Analysing data from interviews with staff/patients and ethnographic observations at 13 Long COVID clinics, LOCOMOTION researchers found that clinics made progress towards standardizing assessment and management in some topics; some variation remained but this could usually be explained.
Clinics had different histories and path dependencies, occupied a different place in their healthcare ecosystem and served a varied caseload including a high proportion of patients with comorbidities. A key mechanism for achieving high-quality Long COIVD care was when local Multi-Disciplinary Teams deliberated on unusual, complex or challenging cases for which evidence-based guidelines provided no easy answers.
Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review
Published in the International Journal of Environmental Research and Public Health.
A metareview of 16 systematic reviews and a systematic review of an additional 47 individual studies was conducted by LOCOMOTION researchers. Scoping the literature linking Long COVID symptoms with pathophysiology and grouping them by the system involved, pathology, and potential therapy.
Their conclusion was that Long COVID is a complex condition affecting multiple organs with diverse clinical presentations (or traits) underpinned by multiple pathophysiological mechanisms, and a ‘treatable trait’ approach may help identify certain groups and target specific interventions. Future research must include understanding the response to intervention based on these mechanism-based traits.
Work and vocational rehabilitation for people living with Long COVID
Published in the British Medical Journal (BMJ).
This new BMJ Practice Pointer provides an overview of the impacts of Long COVID on people’s ability to work and the types of patient scenarios clinicians may encounter. It also outlines how clinicians can respond to questions patients ask about work, and suggests resources.
Published in BMJ Open Respiratory Research.
Using data collected in the LOCOMOTION study on the C19-YRS app, researchers:
- Derived scale characteristics for the C19-YRSm subscales and internal consistency.
- Assessed convergent validity using the FACIT-Fatigue scale.
- Evaluated responsiveness and test-retest reliability for C19-YRSm subscales and EQ-5D-5L.
- Estimated minimal important difference (MID) and minimal clinically important difference (MCID) values.
With the conclusion of the publication being that the C19-YRSm is a condition-specific, reliable, valid, and responsive patient-reported outcome measure for Long COVID.
Prevalence of Orthostatic Intolerance in Long Covid - Animation video
To help share the results from our publication on the Prevalence of Orthostatic Intolerance in Long COVID, Cassie Lee (Clinical Research Fellow) created an animation video explaining the results in a lay format.
Cassie was supported by other members of the team in creating this video, which is voiced by a member of our Patient Advisory Group!
Other LOCOMOTION Activity
Appointment to the WHO Guideline Development Group for Clinical Management of Post COVID-19 Condition.
Prof Manoj Sivan (LOCOMOTION Chief Investigator) has been appointed to the WHO Guideline Development Group (GDG) for clinical management of post COVID-19 condition.
For the development of the WHO Guidelines for clinical management of post COVID-19 condition, a formal GDG comprising individuals with broad expertise spanning multiple specialties and all WHO regions has been convened, which also includes patient panel members.
Read GDG Members Biographies
Presenting at the PoTS UK NW Autonomic Dysfunction Training Programme
In April, Prof Manoj Sivan (LOCOMOTION Chief Investigator) presented at the PoTS UK NW Autonomic Dysfunction Training programme. In the below video, see Manoj present on:
- The NASA Lean Test in Long Covid - Findings from Locomotion study
- Using aAP (adapted Autonomic Profile) and C19-YRS (COVID-19 Yorkshire Rehabilitation Scale) in Long Covid
- Using WHO Borg Protocol for activity and pacing in Long Covid